BackgroundDocetaxel was used to treat metastatic CRPC patients. However, Doc resistance in prostate cancer (PCa) hinders its clinical application.ObjectiveTo understand the underlying mechanisms by which Doc resistance is developed and to find novel therapeutic target to cure Doc resistant PCa has clinical importance.MethodsWe established Doc resistant cell lines and explored the role of Ezh2 in the development of Doc resistance by overexpressing its cDNA or using its inhibitor.ResultsWe found that Ezh2 was induced in our established Doc resistant (DocR) cells, which was attributable to the silenced expression of miR-101-3p and miR-138-5p. Blockage of Ezh2 activity by either inhibitor or miRNA mimics could overcome Doc resistance by suppressing Doc-induced cancer stem cells populations. Mechanistically, Ezh2 activity was required for the induced expression of Nanog, Sox2 and CD44 upon Doc treatment.ConclusionsTargeting Ezh2 could overcome Doc resistance.Electronic supplementary materialThe online version of this article (10.1186/s12885-018-5228-2) contains supplementary material, which is available to authorized users.

A microstrip array antenna with low sidelobe level (SLL) for X‐band marine radar is proposed. The antenna is composed of a 32‐element patch array and a three‐layer near‐zero‐index metamaterial (NZIM). The IABC‐Kmeans algorithm, which combines the improved artificial bee colony algorithm and K‐means clustering algorithm, is used to optimize the current amplitude of the array elements to obtain a lower SLL. The NZIM is loaded in front of the array antenna to reduce the beamwidth of the E‐plane. The antenna is designed and fabricated. The measurement results show that the gain of the antenna at the center frequency is 22.7 dBi, the SLLs of H‐plane and E‐plane are −30.66 dB and − 26.78 dB respectively, and the half‐power beamwidth of H‐plane is 5.9°. Compared with the previous similar antenna structures, the antenna has lower SLL under the premise of narrow beam and high gain, which is very suitable for X‐band marine radar of small and medium fishing vessels.

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Carbon-fiber-reinforced polymer (CFRP) grid and engineered cementitious composite (ECC) were combined in this study to strengthen concrete columns. The influences of the number of layers, the overlap length of CFRP grids, and the eccentricity on the bearing capacity and rigidity of reinforced concrete columns were determined. The results show that the principal failure of the reinforced column was debonding of external ECC from FRP grids at the compressive area, edges, or sides. Significant enhancement in the ultimate bearing capacity and rigidity of eccentrically loaded columns was observed after they were externally reinforced by CFRP grids and ECC; such enhancement increased with the number of reinforced layers. Eccentricity made little difference to the enhancement rate of bearing capacity when the number of reinforced layers was the same. At different eccentricities, the composite layers at the tensile area and the compressive area had different contributions to the bearing capacity. An effective bond and efficient stress transfer could be ensured as long as the overlap length between CFRP grids reached 120 mm.