This feature article highlights the synthesis of structurally unique coumarin-fused coumarins. The structure–activity relationships of these moieties for diverse applications based on their photophysical properties have been emphasized.

A transition-metal free synthetic strategy for the direct synthesis of 3-substituted-3-hydroxy-indolin-2-ones via three component coupling of N-protected isatin, aryne precursor, and 1,3-cyclodione.

The versatility of isocoumarin frameworks offers the privilege to access many pharmacological targets. This unique heterocycle core present in many natural products and complex organic molecules contribute to medicinal chemistry as anti-cancer, anti-inflammatory and immunomodulatory agents. The attractive properties exhibited by its analogues urged the scientists to explore their synthetic analogues. In regard to the myriads of synthetic methodologies, we have compiled a review update covering all the articles that have been published towards the synthesis of 3substituted and 3,4-disubstituted isocoumarins. Additionally, we have also highlighted a systematic survey of catalytic methods for their synthesis along with their scope towards diverse functionalizations and plausible mechanistic aspects.

A Pd-catalyzed cascade annulation process comprising C−C bond formation followed by 1,6-conjugate addition for πextended benzofulvenes is reported. This process is compatible with a wide range of functionalities for both the p-quinone methides and internal alkynes, leading to diverse π-extended benzofulvenes. Additionally, this strategy is also applicable for aryne annulation with p-quinone methides.