In the evaluation of gliomas, Ga-PSMA-11 PET/CT brain imaging is a potentially useful imaging tool. The use of Ga-PSMA-11 brain PET/CT in evaluation of recurrent glioma seems promising. Absence of physiological uptake of Ga-PSMA-11 in the normal brain parenchyma results in high TBR values and consequently better visualization of glioma lesions.

Over 8,00,000 new cases are diagnosed and 5,50,000 deaths occur annually due to cancer in India. The dramatic increase in morbidity and mortality due to cancer is a matter of concern for the society. Though the burden of cancer involves the entire nation, but the rural and underprivileged population represents majority of patients. Despite an already overwhelming burden of health problems, it is high time we must address the cancer pandemic and its alarming share of morbidity and mortality. Many large scale and innovative initiatives have been launched to counter the deadly disease. This includes efforts to expand the resources for health education and increase awareness of cancer prevention to the people and health care providers. These initiatives call for an unprecedented level of cooperation among international agencies, government and nongovernmental organizations, international foundations, healthcare system and local institutions. This review signifies the need for special attention to cancer prevention and early diagnosis with emphasis to rural and remote places of India.

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We present a 53 year old woman initially diagnosed as hemangiopericytoma in the posterior fossa on the right side post excision with immunohistochemistry staining for CD34 being positive. Presently, the patient had difficulty in walking due to back pain and pain in left arm. Imaging with F-FDG PET showed low glucose avidity in disease sites but Ga-PSMA PET unequivocally demonstrated multiple skeletal and liver metastases with intense PSMA avidity. Patient received palliative radiotherapy to bone metastasis and was planned for chemotherapy. This report adds to the list of applications of Ga PSMA PET and a possible theranostic target.

Objective Treatment of recurrent diseases in patients with cervical or endometrial cancers after primary treatment by radiotherapy is challenging due to limitations of treatment options and success rates. Results are variable with contrasting outcomes and toxicities. Methods The authors reviewed all recent evidences and summarized the recent series of studies along with recent advancements and future possibilities. Results Surgical options were traditionally limited to extensive resections such as pelvic exenteration with or without intraoperative radiotherapy (IORT) or radical radiotherapy. IORT can be used as an adjunct to surgery in recurrent malignancies with positive margins. Recent interstitial brachytherapy (ISBT) studies for central recurrences have demonstrated a moderate 2 to 3 years local control of~50%. Stereotactic body radiotherapy (SBRT) has also emerged as an attractive and apparently viable alternative, especially in treating relapsed nodes and pelvic sidewall disease, achieving 1-and 2-year local control rates of about 80 and 50%, respectively. Conclusion The results of salvage re irradiation are reasonable. More upcoming evidences and ongoing technological innovations will guide us in more effective retreatment and addition to life in this group of patients.