The aim of epilepsy surgery is not only to control seizures but also to curtail future adverse neurological sequelae and improve quality of life. Epilepsy surgery is a viable treatment option for selected cases of medically refractory epilepsy. A study was carried out with a series of 34 cases who underwent epilepsy surgery at Sree
Background: Epilepsy is a common chronic neurological disorder worldwide. Carbamazepine is one of the most commonly used antiepileptic drugs. It is a hepatic cytochrome P 450 enzyme inducer which is thought to cause alteration of serum lipids.
Objective: To evaluate the effect of carbamazepine on serum cholesterol and atherogenic ratios in young adult epileptic patients.
Materials and methods: This prospective study was conducted in the epilepsy clinic and Neurology OPD of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from December, 2017 to March, 2019. A total fifty seven newly diagnosed epileptic patients fulfilling the study criteria were studied. Serum TC, HDL-C, TG was measured by using Beckman Coulter- AU680 analyzer machine and LDL-C was calculated according to the Friedewald formula in the laboratory of Department of Biochemistry, BSMMU.
Results: The mean (±SD) serum TC, LDL, TG, TC/HDL-C and LDL-C/HDL-C were significantly increased (p-value < 0.001) at 3 months of carbamazepine therapy in comparison to the baseline levels. The mean (±SD) serum HDL was decreased at 3 months of therapy which was not statistically significant (p-value: 0.135).
Conclusion: Carbamazepine caused significant rise in serum TC, LDL-C, TG and atherogenic ratios (TC/HDL-C, LDL-C/HDL-C), and insignificant reduction in the serum HDL-C level after three months of therapy.
Bangladesh Journal of Neuroscience 2018; Vol. 34 (1): 32-38
Aims: Vertigo is an abnormal perception of the movement of the environment or self and may result from diseases of the labyrinth, vestibular nerve or its central connections, vertebrobasilar insufficiency, and anxiety disorder. In this study, we aimed to evaluate the epidemiological and clinical characteristics of vertigo patients. Study Design: Descriptive cross-sectional study. Methodology: This cross-sectional study was done at the Neurology outpatient department (OPD) of Bangabandhu Sheikh Mujib Medical University (BSMMU) from September 2013 to August 2015. All the patients presenting with vertigo were evaluated by history, clinical examinations, Dix-Hallpike test, and appropriate investigations.
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