Kaori Asakawa scite author profile

Alkaloids U 0600Formal Total Synthesis of (-)-Physostigmine (VII). -Key steps are the pig liver esterase mediated asymmetric hydrolysis of diester (II) and the CuI-mediated intramolecular amidation of (IV). (-)-Physostigmine (VII) has been evaluated in clinical trials for the symptomatic treatment of Alzheimer's disease and shows a wide range of biological activities. -(ASAKAWA, K.; NOGUCHI, N.; NAKADA*, M.; Heterocycles 76 (2008) 1, 183-190; Dep. Chem. Biochem., Waseda Univ., Shinjuku, Tokyo 169, Japan; Eng.) -M. Bohle 09-212

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Kaori Asakawa

Preparation of a new chiral building block containing a benzylic quaternary stereogenic center and a formal total synthesis of (−)-physostigmine

Formal Total Synthesis of (—)-Physostigmine

ChemInform Abstract: Formal Total Synthesis of (‐)‐Physostigmine (VII).

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