No abstract

The design and synthesis of a new linker unit that will enable uniform and robust immobilization of organic functional molecules onto silica supports is described. This linker unit works as a rigid scaffold to prevent grafted organic functional moieties from leaving the support.

The Pd phosphine complex catalysts immobilized onto polyethylene glycol (PEG)-modified silica were prepared in order to clarify the effect of the PEG modification on the Suzuki-Miyaura coupling reaction in organic solvents. For the reaction of ethyl p-bromobenzoate and phenylboronic acid in the presence of potassium carbonate in toluene, the PEG-modified silica-immobilized Pd catalysts exhibited much higher activities than the catalysts without PEG modification.

MIYAZAWA*, A.; SAITOU, K.; TANAKA, K.; GAEDDA, T. M.; TASHIRO, M.; PRAKASH, G. K. S.; OLAH, G. A.; Tetrahedron Lett. 47 (2006) 9, 1437-1439; Natl. Inst. Adv. Ind. Sci. Technol., Tsukuba, Ibaraki 305, Japan; Eng.) -R. Staver 24-078

Clinical symptoms and multiple sleep latency test (MSLT) measures among narcoleptic patients with both cataplexy and HLADR1501 were compared with cataplexy-free narcoleptic patients with a positive finding of HLADR1501 and cataplexy-free patients without HLADR1501. Both mean sleep onset latencies and rapid eye movement (REM) latencies on MSLT were shorter in the patients with cataplexy compared with the cataplexy-free patients. In four cataplexy-free patients without HLADR1501, nocturnal sleep was remarkably long and their excessive daytime sleepiness did not respond to treatment. The findings suggest that the severity and disease mechanism of narcolepsy might become heterogenous when cataplexy and HLADR1501 are considered.