The socioeconomic burden of cancer is growing rapidly in the Asian region, with a concentrated burden on low-and middle-income countries. The residents of this region, representing almost 60% of the global population, demonstrate an eclectic and complex nature, with huge disparities in ethnicity, sociocultural practices among others. The Asian National Cancer Centers Alliance (ANCCA) was established in 2005 by heads of several national cancer centers (NCCs) in the region to address common issues and concerns among Asian countries. During the first 13 years of ANCCA's existence, the participating NCCs' senior managers paved the way toward collaboration through transparent sharing of key facts and activities. Concrete achievements of the Alliance include the Asia Tobacco-Free Declaration, the establishment of the ANCCA Constitution in 2014 as well as the creation of an official website more recently. In November 2019, the most active ANCCA members (

Background Late-stage breast cancer (BC) is commonly diagnosed in limited-resource countries such as Indonesia. The lack of information for decision-making emphasizes the need for efforts to support evidence-informed practice for improving BC early detection in Indonesia. This study attempts to understand the local context evidence on policy implementation, challenges, and plans for enhancing BC early detection programs in Indonesia. The evidence gained from this study will help harness the power of scientific reasoning that shapes theories of how BC early detection intervention works and its operationalization in practice. Methods This study engaged three interrelated phases of qualitative methods. Phase I involved a document analysis in determining the predominant strategy and approach to the landscape of BC early detection programs. Phase II was an in-depth interview to clarify the operationalization of the technical aspect, eliciting stakeholder experiences and their perceptions about the factors supporting or hindering goal achievement. In phase III, two consecutive collaborative expert workshops and a collaborative learning process nested with the Indonesia Project ECHO team for Knowledge Summaries for Comprehensive Breast Cancer Control. Results Current BC early detection strategies to downstage women's symptomatic breast abnormalities are considered an essential preparatory step before starting a screening program at the enhanced or maximal level of resources. However, the absence of an integrated cancer registry system renders it impossible to measure the full effect of the program implementation as a public health policy. Emphasis on improving structural barriers during the follow-up of abnormalities, patient navigation for referrals, and a surveillance system to track the times from presentation to diagnosis and diagnosis to treatment is needed for Indonesia's early detection services continuum. Conclusion The local context presented in this research increased the usability and usefulness of relevant evidence for decision-makers, thus bridging the gap in translating research findings into healthcare practice for BC early detection in Indonesia. Importantly, attention to providing a clear national guideline, developing a highly interoperable screening registry system, and ensuring the sustainability of pilot sites on mammography screening is critical to the success of expected outcomes.

One of the quality control measures in F-18 radionuclide production concerns the impurities which might be present in the proton-irradiated enriched H2 18 O target. In this investigation, proton irradiations of enriched water targets were theoretically simulated by the Stopping and Range of Ions in Matter (SRIM) 2013 codes, followed by experimental measurements. First, the SRIM-calculated data were employed to understand the origins of the recoiled and sputtered species. Using a portable Gamma Ray Spectroscopy System, recoiled and sputtered radioactive impurities were measured in the enriched water target following F-18 production using 11 MeV proton beams. The experimental results indicate that Havar window-originated Co-56 radionuclide and silver body-originated Ag-110m radioisotope were identified in the postirradiated enriched H2 18 O target. In addition, after passing the 18 F solution through a column containing Quaternary Methyl Acetate (QMA) resin, none of the radionuclidic impurities were any longer observed to any great extent in the sample.

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