The formation of vesicles as a tool to improve the drug delivery system. Niosomes are a system aimed at delivering drugs. Niosomes of non-ionic vesicles are highly affected by the hydration of nonionic syntactants, or unmixed cholesterol or other lipids. Niosomes promise a drug delivery and non-ionic vehicle, is less toxic and improves drug treatment index by inhibiting its action to target cells and play a key role in regulating nutrient release. Niosomes are preferred over liposomes because the former exhibit high chemicalstability and economy. The application of vesicular (lipid vesicles and non-ionic surfactantvesicles) systems in cosmetics and for therapeutic purpose may offer several advantages.They improve the therapeutic performance of the drug molecules by delayed clearance from the circulation, protecting the drug from biological environment and restricting effects to target cells. This article focuses on the recent advances in niosomal drug delivery, potential advantages over other delivery systems, formulation methods, methods of characterization and the current research in the field of niosomes.