Globally, the impact of COVID‐19 on healthcare workers' mental health has been a major focus of recent research. However, Australian research involving nurses, particularly across the acute care sector, is limited. This cross‐sectional research aimed to explore the impact of pandemic‐related stress on psychological adjustment outcomes and potential protective factors for nurses ( n = 767) working in the Australian acute care sector during the COVID‐19 pandemic. Nurses completed an online questionnaire with psychometrically validated measures of pandemic‐related stress, psychological adjustment outcomes (depression, anxiety, and subjective well‐being), and protective factors (posttraumatic growth and self‐compassion). Descriptive analyses revealed that pandemic‐related stress was reported by 17.7% of the participants. Psychological adjustment outcome scores above normal for depression (27.5%) and anxiety (22.0%) were found, and 36.4% of the participants reported poor subjective well‐being. Regression analyses suggest that pandemic‐related stress predicted greater depression ( B = 0.32, SE = 0.02, 95% confidence interval [0.28, 0.35]) and anxiety ( B = 0.26, SE = 0.01, 95% confidence interval [0.24, 0.29]) and less subjective well‐being ( B = −0.14, SE = 0.01, 95% confidence interval [−0.16, −0.12]). Self‐compassion weakened the relationship between pandemic‐related stress and greater depression, however, exacerbated the relationship between pandemic‐related stress and less subjective well‐being. Posttraumatic growth reduced the negative relationship between pandemic‐related stress and psychological adjustment outcomes. These findings will inform strategies to facilitate psychological resources that support nurses' psychological adjustment, enabling better pandemic preparedness at both an individual and organizational level.

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MW01‐6‐189WH (MW189) is a novel central nervous system–penetrant small‐molecule drug candidate that selectively attenuates stressor‐induced proinflammatory cytokine overproduction and is efficacious in intracerebral hemorrhage and traumatic brain injury animal models. We report first‐in‐human, randomized, double‐blind, placebo‐controlled phase 1 studies to evaluate the safety, tolerability, and pharmacokinetics (PK) of single and multiple ascending intravenous doses of MW189 in healthy adult volunteers. MW189 was safe and well tolerated in single and multiple doses up to 0.25 mg/kg, with no clinically significant concerns. The most common drug‐related treatment‐emergent adverse event was infusion‐site reactions, likely related to drug solution acidity. No clinically concerning changes were seen in vital signs, electrocardiograms, physical or neurological examinations, or safety laboratory results. PK analysis showed dose‐proportional increases in plasma concentrations of MW189 after single or multiple doses, with approximately linear kinetics and no significant drug accumulation. Steady state was achieved by dose 3 for all dosing cohorts. A pilot pharmacodynamic study administering low‐dose endotoxin to induce a systemic inflammatory response was done to evaluate the effects of a single intravenous dose of MW189 on plasma cytokine levels. MW189 treatment resulted in lower levels of the proinflammatory cytokine TNF‐α and higher levels of the anti‐inflammatory cytokine IL‐10 compared with placebo treatment. The outcomes are consistent with the pharmacological mechanism of MW189. Overall, the safety profile, PK properties, and pharmacodynamic effect support further development of MW189 for patients with acute brain injury.

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Among the illustrations used for a 4to Missale Romanum published by Christopher Plantin in 1585 are five prints by Jan Wierix and four anonymous copies of his work, none of which are in Marie Mauquoy-Hendrickx's extensive catalogue, Les Estampes des Wierix (Brussels 1978-83). This new group of religious prints and an already known group of comparably scaled Wierix engravings appear formerly to have been part of a single series of images. A consideration of both the subjects represented and archival evidence suggests that the series had been commissioned for the illustration of books of hours and not the missals in which the engravings are seen today. Finally, a similar examination of the subjects represented in two other sets of Wierix plates catalogued by Mauquoy-Hendrickx (but not part of any known book) suggests that they may also have originally been intended for the illustration of books of hours.