Objective: To compare levels of particulate matter, as a marker of secondhand smoke (SHS) levels, in pubs before and 2 months after the implementation of Scottish legislation to prohibit smoking in substantially enclosed public places. Design: Comparison of SHS levels before and after the legislation in a random selection of 41 pubs in 2 Scottish cities. Methods: Fine particulate matter ,2.5 mm in diameter (PM 2.5 ) was measured discreetly for 30 min in each bar on 1 or 2 visits in the 8 weeks preceding the starting date of the Smoking, Health and Social Care (Scotland) Act 2005 and then again 2 months after the ban. Repeat visits were undertaken on the same day of the week and at approximately the same time of the day. Results: PM 2.5 levels before the introduction of the legislation averaged 246 mg/m 3 (range 8-902 mg/m 3 ). The average level reduced to 20 mg/m 3 (range 6-104 mg/m 3 ) in the period after the ban. Levels of SHS were reduced in all 53 post-ban visits, with the average reduction being 86% (range 12-99%). PM 2.5 concentrations in most pubs post-ban were comparable to the outside ambient air PM 2.5 level.Conclusions: This study has produced the largest dataset of pre-and post-ban SHS levels in pubs of all worldwide smoke-free legislations introduced to date. Our results show that compliance with the Smoking, Health and Social Care (Scotland) Act 2005 has been high and this has led to a marked reduction in SHS concentrations in Scottish pubs, thereby reducing both the occupational exposure of workers in the hospitality sector and that of non-smoking patrons. 2 Data on exposure to SHS across a wide range of entertainment establishments indicated that airborne nicotine concentrations were up to 18.5 times higher than in offices or domestic residences.3 Studies have shown that non-smoking bar workers have salivary cotinine levels four times those of non-smokers who live with partners who smoke. 4 Data from New Zealand indicate that non-smoking hospitality workers in establishments that permit smoking have salivary cotinine levels between 3 and 4 times those of non-smoking workers in smoke-free premises.5 One estimate indicates that between 1500 and 2000 non-smokers' deaths per year in Scotland can be attributed to SHS exposure. 6 It has been suggested that SHS exposure may lead to the deaths of over 50 hospitality sector workers in the UK each year. The introduction of smoke-free legislation in other countries has been shown to dramatically reduce SHS levels. A recent analysis of the effect of the Norwegian legislation 8 showed that total dust levels in 13 bars and restaurants reduced from an average level of 262 to 77 mg/m 3 , a 70% reduction, whereas a study in the USA indicated that respirable dust levels in a selection of 8 hospitality venues reduced to approximately 9% of the pre-ban level.9 Similar work in New York State in a mixture of bars and restaurants measured levels of particulate matter ,2.5 mm in diameter (PM 2.5 ), and found that mean levels decreased from 412 to 27 mg/m 3 (93.5%). Alth...

As part of a larger study aimed at identifying the long-term changes in inhalation exposure for selected hazardous substances in a number of industrial sectors within the UK, we have reviewed the published literature on temporal changes in inhalation exposure. Scientific papers and reports of interest were identified using standard literature review techniques. Most studies did not express the results as relative annual trends in exposure, and so where possible the data were reanalysed using regression methods to produce estimates of the average annual percentage change in concentration. In the majority of instances, there were significant reductions in exposure, with percentage yearly declines up to 32%. In many studies, information about changes in the working environment, process conditions or other factors that may have influenced the change in exposure over time was lacking. Factors commonly cited as being responsible for exposure reductions included the introduction of new standards and response to regulatory requirements as well as changes in production methods. A large number of exposure measurement datasets exist for many industrial sectors for most of the second half of the 20th century and this resource has allowed us to identify trends in occupational exposure. It is most important that longitudinal exposure data continue to be collected along with relevant contextual information to enable future changes to be adequately assessed.

Background: A ban on smoking in wholly or substantially enclosed public places has been in place in Scotland since 26 th March 2006. The impact of this legislation is currently being evaluated in seven studies, three of which involve direct observation of smoking in bars and other enclosed public places. While the ethical issues around covert observation have been widely discussed there is little practical guidance on the conduct of such research. A workshop was therefore convened to identify practical lessons learned so far from the Scottish evaluation.

Isocyanates, as a chemical group, are considered to be the biggest cause of occupational asthma in the UK. Monitoring of airborne exposures to total isocyanate is costly, requiring considerable expertise, both in terms of sample collection and chemical analysis and cannot be used to assess the effectiveness of protection from wearing respiratory protective equipment (RPE). Biological monitoring by analysis of metabolites in urine can be a relatively simple and inexpensive way to assess exposure to isocyanates. It may also be a useful way to evaluate the effectiveness of control measures in place. In this study biological and inhalation monitoring were undertaken to assess exposure in a variety of workplaces in the non-motor vehicle repair sector. Companies selected to participate in the survey included only those judged to be using good working practices when using isocyanate formulations. This included companies that used isocyanates to produce moulded polyurethane products, insulation material and those involved in industrial painting. Air samples were collected by personal monitoring and were analysed for total isocyanate content. Urine samples were collected soon after exposure and analysed for the metabolites of different isocyanate species, allowing calculation of the total metabolite concentration. Details of the control measures used and observed contamination of exposed skin were also recorded. A total of 21 companies agreed to participate in the study, with exposure measurements being collected from 22 sites. The airborne isocyanate concentrations were generally very low (range 0.0005-0.066 mg m(-3)). A total of 50 of the 70 samples were <0.001 mg m(-3), the limit of quantification (LOQ), therefore samples below the LOQ were assigned a value of 1/2 LOQ (0.0005 mg m(-3)). Of the 70 samples, 67 were below the current workplace exposure limit of 0.02 mg m(-3). The highest inhalation exposures occurred during spray painting activities in a truck manufacturing company (0.066 mg m(-3)) and also during spray application of polyurethane foam insulation (0.023 mg m(-3)). The most commonly detected isocyanate in the urine was hexamethylene diisocyanate, which was detected in 21 instances. The geometric mean total isocyanate metabolite concentration for the dataset was 0.29 micromol mol(-1) creatinine (range 0.05-12.64 micromol mol(-1) creatinine). A total of 23 samples collected were above the agreed biological monitoring guidance value of 1.0 micromol mol(-1) creatinine. Activities that resulted in the highest biological monitoring results of the dataset included mixing and casting of polyurethane products (12.64 micromol mol(-1) creatinine), semi-automatic moulding (4.80 micromol mol(-1) creatinine) and resin application (3.91 micromol mol(-1) creatinine). The biological monitoring results show that despite low airborne isocyanate concentrations, it was possible to demonstrate biological uptake. This tends to suggest high sensitivity of the biological monitoring method and/or that in some instances the RPE bein...

The estimation and assessment of substance exposure (EASE) model has been under development and in use since the early 1990s. It is a general model that can be used to predict workplace exposure to any substance hazardous to health. The current EASE model (version 2.0) has been used widely in the risk assessment of new and existing chemicals by the UK Health and Safety Executive (HSE) and other regulatory agencies. EASE has also been distributed globally to over 200 users and therefore may have been used for many other purposes. Despite widespread use of the model, neither the development of its structure nor its underlying concepts and principles have been published in the open literature. Using surviving documentary evidence and discussions with key personnel, the creation and development of the model from 1992 to 2002 is described. The role of the HSE's National Exposure Database (NEDB) as the principal data source for the development of the model output exposure ranges is described. A number of problems and limitations of the model have been identified and the description of the model's development provides some explanation of their presence.