Increased curiosity on natural plant products has been raised due to problems of cost, unavailability, and after-effects of countless synthetic drugs. Worrisome, many plant-derived formulations lack phytochemically or toxicological screening. Hence, this study phytochemical and elemental screened the ethanolic leaf extract of Acalypha wilkesiana and as well as determining acute toxicity in adult male Wistar rats. The leaves were obtained in Benin City, Nigeria. Ethanol extraction was carried out on leaves and the extract was subjected to proximate, qualitative, and quantitative phytochemical screening and elemental analysis. Acute toxicity was determined on 12 adult male Wistar rats following Lork’s method. Proximate analysis revealed a high presence of carbohydrate, ash, fiber, and moisture. The qualitative and quantitative evaluation showed the abundance of alkaloids (68.7 ± 0.120%), flavonoids (34.7 ± 0.001%) and minute (<1mg/g) saponins, tannins, phenol, and terpenes. The extract contain nutritive (vitamin E = 1.184 ± 0.055µg/g; vitamin A = 0.0066 ± 0.003µg/g; vitamin C = 0.046 ± 0.037µg/g) and anti-nutritive (oxalates = 229.780 ± 16.93mg/100g; cyanide=0.162 ± 0.006 mg/100g; phytate = 0.131 ± 0.01mg/100g) elements. The elemental evaluation showed an abundance of potassium, sodium, and chloride with traces of cadmium and lead and the absence of manganese and copper. There was no sign of acute toxicity or mortality at an extract dose of 5000mg/kg. These findings indicate the ethanol leaf extract of A. wilkesiana as a rich source of phytochemicals and major macro elements and high safety at 5000mg/kg dose. Considering the several components in the leaves extract, Acalypha wilkesiana leaf might be pharmacological significant for the biological system.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.