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Graetz C, Dörfer CE, Kahl M, Kocher T, Fawzy El‐Sayed K, Wiebe J‐F, Gomer K, Rühling A. Retention of questionable and hopeless teeth in compliant patients treated for aggressive periodontitis. J Clin Periodontol 2011; 38: 707–714. doi: 10.1111/j.1600‐051X.2011.01743.x. Abstract Aim: The aim of this study was to determine the survival rates of questionable and hopeless teeth in patients with aggressive periodontitis (AgP) and chronic periodontitis (CP) during 15 years of supportive periodontal therapy (SPT). Materials and methods: Thirty‐four AgP and 34 CP patients (SPT10 years) with bone loss of 50% at 2 teeth were consecutively recruited. Bone loss was measured on digitized radiographs and teeth were categorized as “questionable” (50 to <70% bone loss) or as “hopeless” (70%). Progression in pocket probing depths (PPD) during SPT, tooth loss and reasons for extraction were analysed. Results: In AgP patients, 262 teeth were considered as questionable and 63 as hopeless (CP: 149/51). During active periodontal therapy, 25 questionable and 26 hopeless teeth were extracted (CP: 12/16). During 15.3 ± 4.1 years of SPT of AgP 28 questionable and 15 hopeless teeth were removed (CP: 28/12). The mean tooth loss per patient during SPT in total was 0.14 (AgP) and 0.16 (CP) teeth/year. There were no significant differences in tooth loss or longitudinal progression of PPD between AgP and CP patients. Conclusions: In patients with AgP, 88.2% (209 of 237) of questionable and 59.5% (22 of 37) of hopeless teeth survived 15 years during regular SPT in a dental school department.

The human gingiva, characterized by its outstanding scarless wound healing properties, is a unique tissue and a pivotal component of the periodontal apparatus, investing and surrounding the teeth in their sockets in the alveolar bone. In the last years gingival mesenchymal stem/progenitor cells (G-MSCs), with promising regenerative and immunomodulatory properties, have been isolated and characterized from the gingival lamina propria. These cells, in contrast to other mesenchymal stem/progenitor cell sources, are abundant, readily accessible, and easily obtainable via minimally invasive cell isolation techniques. The present review summarizes the current scientific evidence on G-MSCs' isolation, their characterization, the investigated subpopulations, the generated induced pluripotent stem cells- (iPSC-) like G-MSCs, their regenerative properties, and current approaches for G-MSCs' delivery. The review further demonstrates their immunomodulatory properties, the transplantation preconditioning attempts via multiple biomolecules to enhance their attributes, and the experimental therapeutic applications conducted to treat multiple diseases in experimental animal models in vivo. G-MSCs show remarkable tissue reparative/regenerative potential, noteworthy immunomodulatory properties, and primary experimental therapeutic applications of G-MSCs are very promising, pointing at future biologically based therapeutic techniques, being potentially superior to conventional clinical treatment modalities.

Aim A range of predictors for tooth loss in periodontitis patients have been reported. We performed a systematic review and meta‐analysis to assess the consistency and magnitude of any association between a total of 12 predictors and tooth loss. Materials and Methods Medline/Embase/Central were searched for longitudinal studies investigating the association between predictors and tooth loss in periodontitis patients. Random‐effects meta‐analysis was performed, and study quality assessed. Results Twenty studies (15,422 patients, mean follow‐up: 12 years) were included. The mean annual tooth loss/patient was 0.12 (min./max: 0.01/0.36). Older patients (n = 8 studies; OR: 1.05, 95% CI: 1.03–1.08/year), non‐compliant ones (n = 11; 1.51, 1.06–2.16), diabetics (n = 7; 1.80, 1.26–2.57), those with IL‐1‐polymorphism (n = 3; 1.80; 1.29–2.52) and smokers (n = 15; 1.98, 1.58–2.48) had a significantly higher risk of tooth loss. Teeth with bone loss (n = 3; 1.04, 1.03–1.05/%), high probing pocket depth (n = 6; 3.19, 1.70–5.98), mobility (n = 4; 3.71, 1.65–8.38) and molars (n = 4; 4.22, 2.12–8.39), especially with furcation involvement (n = 5; 2.68, 1.75–4.08) also showed higher risks. Gender (n = 16; 0.95, 0.86–1.05) and endodontic affection (n = 3; 3.62, 0.99–13.2) were not significantly associated with tooth loss. Conclusions Older, non‐compliant, smoking or diabetic patients, and teeth with bone loss, high probing pocket depth, mobility, or molars, especially with furcation involvement showed higher risks of tooth loss.