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were investigated as the source of peroxidase (POD: EC 1.11.1.7). Among those, zucchini (Cucurbita pepo) crude extract was found to be the best one. This enzyme in the presence of hydrogen peroxide catalyses the oxidation of paracetamol to N-acetylp-benzoquinoneimine which the electrochemical reduction back to paracetamol was obtained at a peak potential of -0.10V. A cyclic voltammetric study was performed by scanning the potential from + 0.5 to -0.5 V. The recovery of paracetamol from two samples ranged from 97.3 to 106% and a rectilinear calibration curve for paracetamol concentration from 1.2x10 -4 to 2.5x10 -3 mol L -1 (r=0.9965) were obtained. The detection limit was 6.9x10 -5 mol L -1 and the relative standard deviation was less than 1.1% for a solution containing 2.5x10 -3 mol L -1 paracetamol and 2.0x10 -3 mol L -1 hydrogen peroxide (n=12). The results obtained for paracetamol in pharmaceutical products using the proposed biosensor and Pharmacopoeial procedures are in agreement at the 95% confidence level.