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Pemphigoid Gestational (PG), an uncommon autoimmune bullous dermatosis of pregnancy, stands out between the specific dermatological diseases of the gestational period. Despite being self-limited and benign, it has a significant impact on women's health, both physiologically and psychologically. In addition, it promotes pathological changes that can be complicated during pregnancy. This paper reports the case of a pregnant patient with blistering lesions throughout the whole body. The diagnostic hypothesis initially involved PG and the specific treatment with corticosteroids was initiated, but after the anatomopathological result of the biopsy there has been diagnostic confusion with drug hypersensitivity, since clinical and histological manifestations were exuberant for both pathologies. As the lesions recurred in the puerperium, due to the corticoid abstention that was administered for the treatment of the differential diagnosis, a diagnostic review with immunofluorescence was made and confirmed PG. It is important to establish a correct diagnosis therefore, in order to improve the quality of care offered to the mother-baby binomial.

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