No abstract

Findings suggest that current smoking, having an anxiety disorder, and having a mood disorder are independently associated with poorer asthma control but that cumulative smoking history (i.e., pack-years) was not associated with worse asthma control. These results indicate that smoking cessation may have a positive impact on asthma control levels in spite of past smoking intensity and highlight the importance of interventions that target anxiety and mood disorders in adult asthmatics.

Although there is evidence that depression is associated with an increased risk for coronary artery disease (CAD), the mechanisms underlying this association remain unclear. This study examined the association between depression and hemodynamic, hemostatic, and endothelial responses to psychological stress. Seventy-two postcoronary angiography patients completed a mental stress task. Blood pressure, heart rate, and impedance cardiography were recorded at rest and during the task. Blood samples were taken at the end of rest and immediately after the task. Depression was evaluated using the Diagnostic Interview Schedule Self-Administered (DISSA). In total, 21% of the participants were depressed. Analyses revealed that depression was associated with blunted pre-ejection period stress reactivity and with increased platelet factor 4 reactivity. These data provide potential mechanistic pathways linking depression to increased CAD.