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The distribution of cardiac output was studied in unanaesthetized rabbits, in rabbits anaesthetized with pentobarbital and kept at normal body temperature for 2 or 4 h, and in anaesthetized animals kept at a body temperature of 25 °C for 30 min or 2 h. The distribution of blood flow to the different organs of the rabbits was determined by ¹³¹I-labelled macroaggregates of albumins, given intracardially in a single dose. The radioactivity of the organs was determined directly in organ samples, or the organs were dissolved in nitric acid and samples of the solutions tested for radioactivity. Anaesthesia decreased the flow fractions to lungs, forelimb muscles and abdominal muscles and increased the fractions to kidneys, small intestine, large intestine and caecum. Hypothermia decreased the flow fractions to bone and small intestine and increased the flow fractions to heart, forelimb muscles and abdominal muscles. It was concluded that pentobarbital anaesthesia causes a redistribution of blood from skeletal muscles to kidneys and intestines. Hypothermia tends to counteract this effect of the anaesthesia and, in addition, results in a decreased flow fraction to bone and an increased fraction to heart.

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