Es wird ein zusammenhängender Reaktionsweg für die Umwandlung von gesättigten 17-Ketosteroiden in aromatisierte Steroide bei M. smegmatis beschrieben. Ein prinzipiell gleichartiger oxydativer Abbau von Steroiden wurde auch bei anderen Mycobakterien nachgewiesen. Die strukturellen Merkmale der aromatisierten seco-Verbindung werden im Zusammenhang mit der Carcinogenese diskutiert.
Different types of sterol derivatives substituted in position 3 have been investigated to be suitable substrates for microorganisms capable of degradating the side chain of sterols. Sterolesters were found to be either unattacked or hydrolyzed followed by complete degradation of the molecule. Derivatives of the alkylether - and ketal type were transformed to the corresponding C19-steroids by fermentation with strains of the genus Mycobacteria. With respect to stability, solubility and transformation rate the sterol-3-carboxymethyloxime-derivatives were shown to be most suitable.
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