Background: With the current climate change crisis and its influence on infectious disease transmission there is an increased desire to understand its impact on infectious diseases globally. Hantaviruses are found worldwide, causing infectious diseases such as haemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS)/hantavirus pulmonary syndrome (HPS) in tropical regions such as Latin America and the Caribbean (LAC). These regions are inherently vulnerable to climate change impacts, infectious disease outbreaks and natural disasters. Hantaviruses are zoonotic viruses present in multiple rodent hosts resident in Neotropical ecosystems within LAC and are involved in hantavirus transmission. Methods: We conducted a systematic review to assess the association of climatic factors with human hantavirus infections in the LAC region. Literature searches were conducted on MEDLINE and Web of Science databases for published studies according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) criteria. The inclusion criteria included at least eight human hantavirus cases, at least one climatic factor and study from > 1 LAC geographical location. Results: In total, 383 papers were identified within the search criteria, but 13 studies met the inclusion criteria ranging from Brazil, Chile, Argentina, Bolivia and Panama in Latin America and a single study from Barbados in the Caribbean. Multiple mathematical models were utilized in the selected studies with varying power to generate robust risk and case estimates of human hantavirus infections linked to climatic factors. Strong evidence of hantavirus disease association with precipitation and habitat type factors were observed, but mixed evidence was observed for temperature and humidity. Conclusions: The interaction of climate and hantavirus diseases in LAC is likely complex due to the unknown identity of all vertebrate host reservoirs, circulation of multiple hantavirus strains, agricultural practices, climatic changes and challenged public health systems. There is an increasing need for more detailed systematic research on the influence of climate and other co-related social, abiotic, and biotic factors on infectious diseases in LAC to understand the complexity of vector-borne disease transmission in the Neotropics.

The connection between the finite size of an evolving population and its dynamical behavior is examined through analytical and computational studies of a simple model of evolution. The infinite population limit of the model is shown to be governed by a special case of the quasispecies equations. A flat fitness landscape yields identical results for the dynamics of infinite and finite populations. On the other hand, a monotonically increasing fitness landscape shows "epochs" in the dynamics of finite populations that become more pronounced as the rate of mutation decreases. The details of the dynamics are profoundly different for any two simulation runs in that events arising from the stochastic noise in the pseudorandom number sequence are amplified. As the population size is increased or, equivalently, the mutation rate is increased, these epochs become smaller but do not entirely disappear.

Barbados is heavily reliant on groundwater resources for its potable water supply, with over 80% of the island’s water sourced from aquifers. The ability to meet demand will become even more challenging due to the continuing climate crisis. The consequences of climate change within the Caribbean region include sea level rise, as well as hydrometeorological effects such as increased rainfall intensity, and declines in average annual rainfall. Scientifically sound approaches are becoming increasingly important to understand projected changes in supply and demand while concurrently minimizing deleterious impacts on the island’s aquifers. Therefore, the objective of this paper is to develop a physics-based groundwater model and surrogate models using machine learning (ML), which provide decision support to assist with groundwater resources management in Barbados. Results from the study show that a single continuum conceptualization is adequate for representing the island’s hydrogeology as demonstrated by a root mean squared error and mean absolute error of 2.7 m and 2.08 m between the model and observed steady-state hydraulic head. In addition, we show that data-driven surrogates using deep neural networks, elastic networks, and generative adversarial networks are capable of approximating the physics-based model with a high degree of accuracy as shown by R-squared values of 0.96, 0.95, and 0.95, respectively. The framework and tools developed are a critical step towards a digital twin that provides stakeholders with a quantitative tool for optimal management of groundwater under a changing climate in Barbados. These outputs will provide sound evidence-based solutions to aid long-term economic and social development on the island.