See Bezard and Carta for a scientific commentary on this article (doi:).In a double-blind placebo-controlled study, Svenningsson et al. test a single oral dose of eltoprazine—a serotonin 5-HT1A/1B receptor agonist—plus L-DOPA in patients with Parkinson's disease and L-DOPA-induced dyskinesias. Eltoprazine doses of 5 mg and 7.5 mg are well-tolerated, and have antidyskinetic efficacy without altering motor responses to L-DOPA.
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