Introduction. Pigmented purpuric dermatoses (purpura simplex; inflammatory purpura without vasculitis) constitute a heterogenic group of inflammatory skin diseases. Objective. To present a patient with extensive skin lesions secondary to pigmented purpuric dermatosis, Schamberg's disease type. Case report. A 34-year-old man patient was admitted to the Dermatology Clinic in Krakow, Poland, due to disseminated pigmented purpuric lesions. Schamberg's disease was diagnosed on the basis of clinical, dermoscopic and histopathological examinations. The treatment involved preparations improving venous microcirculation, antihistamine drugs, and a series of UVB 311 treatment sessions-partial improvement was achieved. Conclusions. An overview of literature and the presented case show that diagnosing pigmented purpuric dermatoses constitutes a challenge in everyday dermatological practice. The patients require a deepend diagnostic analysis and follow-up also because of possible coexistence or risk of future development of mycosis fungoides. Achieving a therapeutic effects is difficult. Treatment decisions are adjusted individually. streszczenie Wprowadzenie. Postępujące plamice barwnikowe (pigmented purpuric dermatoses, purpura simplex; inflammatory purpura without vasculitis) to heterogenna grupa chorób zapalnych skóry. Cel pracy. Opis przypadku pacjenta z rozległymi zmianami skórnymi w przebiegu postępującej plamicy barwnikowej typu choroby Schamberga. Opis przypadku. Przedstawiono 34-letniego pacjenta, który zgłosił się do krakowskiej Kliniki Dermatologii z powodu rozsianych plamiczych Case report/Opis przypadku Atypical presentation of schamberg's disease-diagnostic challenges nietypowy obraz choroby schamberga-trudności diagnostyczne

Primary cicatricial alopecia (PCA) encompasses a diverse group of inflammatory diseases characterized by the irreversible replacement of hair follicle structures by fibrous tissue. Although the pathogenesis of PCA remains not fully understood, the key to its understanding might be the location of dendritic cells (DCs) inflammatory infiltrate. One of the systemic therapy of choice in PCA patients is hydroxychloroquine (HCQ). We hypothesized that DCs are implicated in PCA pathogenesis and that they might constitute the biological target of HCQ treatment. For these reasons, we investigated whether DCs could affect the antimalarial responsiveness, and if DCs might be used as predictive factor of responsiveness to HCQ. In this retrospective cohort study, 65 patients diagnosed with PCA were grouped accordingly to their response to HCQ therapy. Skin biopsies had been taken before the treatment was started. Cell count was performed on immunohistochemistry by using characteristic monoclonal antibodies to specific subpopulations of DCs. In almost every second

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Verruca is a general term for lesions that are clinical manifestations of an infection with human papillomavirus (HPV). A particularly difficult (both diagnostically and therapeutically) site of verrucae is the nail apparatus within which anatomical conditions significantly hinder successful treatment of these common skin infections. The aim of the article is to present a series of three cases of patients with verrucae within the nail apparatus, including one case with a secondary involvement of the vermillion boarder due to biting and chewing the nail apparatus area. Diagnostics and treatment of nail apparatus verrucae constitute a special challenge in everyday dermatological practice due to its unique and hard-to-reach anatomical site as well as the risk for secondary HPV infections and development of nail unit squamous cell carcinoma. STrESzczEniEBrodawki wirusowe to ogólna nazwa zmian będących kliniczną manifestacją zakażenia wirusem brodawczaka ludzkiego (HPV). Szczególnie trudną (zarówno diagnostycznie, jak i terapeutycznie) lokalizacją brodawek wirusowych jest aparat paznokciowy, w obrębie którego warunki anatomiczne często znacząco utrudniają skuteczne leczenie tych powszechnie występujących infekcji skóry. Celem pracy jest przedstawienie serii trzech przypadków pacjentów z brodawkami wirusowymi w obrębie aparatu paznokciowego, w tym jednego przypadku z wtórnym zajęciem czerwieni wargowej z powodu obryzgania i żucia okolicy aparatu paznokciowego. Diagnostyka i leczenie brodawek wirusowych aparatu paznokciowego stanowi wyzwanie w codziennej praktyce dermatologicznej ze względu na specyficzną, trudno dostępną lokalizację anatomiczną oraz ryzyko rozwoju raka kolczystokomórkowego okolicy płytki paznokciowej wtórnego do infekcji HPV.

Introduction Primary cicatricial alopecia (PCA) encompasses a heterogeneous group of inflammatory diseases characterized by the replacement of hair follicle structures by fibrous tissue. Discoid lupus erythematosus (DLE) and lichen planopilaris (LPP) are the most common causes of scarring alopecia. The distinction between both entities is often challenging because of significant clinical and histopathological overlap. Aim We hypothesized that dendritic cells which are implicated in PCA pathogenesis can provide a reliable histopathological clue to distinguish between these two entities. Material and methods In a retrospective cohort study including 51 patients diagnosed with LPP and DLE we mapped and quantified the distribution of dendritic cells. Cell count in lesional skin was performed on immunohistochemistry by using characteristic monoclonal antibodies to specific subpopulations of dendritic cells. Results We demonstrated that almost all subpopulations of dendritic cells were highly expressed in lesional skin of discoid lupus erythematosus patients in comparison with lichen planopilaris ones. Conclusions In the light of this observation, dendritic cells might be used as an additional clue in differential diagnosis of PCA.