Leishmaniosis is a neglected tropical disease which affects several millions of people worldwide. The current drug therapies are expensive and often lack efficacy, mainly due to the development of parasite resistance. Hence, there is an urgent need for new drugs effective against Leishmania infections. As a part of our ongoing study on the phytochemical characterization and biological investigation of plants used in the traditional medicine of western and central Asia, in the present study, we focused on Eremurus persicus root extract in order to evaluate its potential in the treatment of leishmaniosis. As a result of our study, aloesaponol III 8-methyl ether (ASME) was isolated for the first time from Eremurus persicus root extract, its chemical structure elucidated by means of IR and NMR experiments and the (R) configuration assigned by optical activity measurements: chiroptical aspects were investigated with vibrational circular dichroism (VCD) and electronic circular dichroism (ECD) spectroscopies and DFT (density functional theory) quantum mechanical calculations. Concerning biological investigations, our results clearly proved that (R)-ASME inhibits Leishmania infantum promastigotes viability (IC50 73 µg/mL), inducing morphological alterations and mitochondrial potential deregulation. Moreover, it is not toxic on macrophages at the concentration tested, thus representing a promising molecule against Leishmania infections.

Glossostemon bruguieri named "ARAB QŌZI" or "MOGHAT", which is used in the traditional medicine for treatment various ailments, where no such study has been conducted so far. This investigations report for the first time the anatomical characters and identify the chemical constituents of methanolic extract for different parts of G. bruguieri by using modern sensitive gas chromatography -mass spectroscopy (GC-MS).The microscopic study showed the present of internal duct in all studied parts ,also present of oil drops in the cells of root ,cells with special bodies near the vascular bundle of leaves and its petioles and the present of (Stellate, dendroid and multicellular glandular) trichome in aerial parts of the plant.GC-MS analysis revealed the presence of many compounds in different parts of G. bruguieri different between the parts in relation to the anatomical structure which reflex the importance of the aerial parts of the plant in addition to traditional use of root.

A new heterogeneous catalytic system containing triazine-based copper(II) tridentate-NNN-pincer complex, covalently anchored to the aminefunctionalized silica-coated Fe 3 O 4 magnetic nanoparticles, Fe 3 O 4 @SiO 2 -NH-CCl-AT-Cu(II), was synthesized. Its structure was studied through the standard methods of FT-IR, NMR, EDX, TGA, FE-SEM, MAP images, XRD, ICP, and N 2 adsorption-desorption isotherm analysis and utilized for the production of propargylamines by one-pot A 3 coupling of phenylacetylene, aldehydes, and secondary amines, attaining TOF values of up to 40,000 h À1 . The impact of various solvents, reaction time, temperature, catalyst amount, and recyclability of the catalyst were studied to optimize reaction conditions. The catalyst was re-examined five times, and no noteworthy reduction in activity was observed. K E Y W O R D S2-amino-5-mercapto-1,3,4-thiadiazole (denoted as AT), A 3 coupling reaction, copper(II), propargylamine, triazine-based NNN-pincer ligand