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Extensive research has related the consumption of persimmon with the reduced risk of various diseases and particularly highlighted the presence of bioactive phenolic compounds for their therapeutic properties. Major phenolic compounds present in persimmon are ferulic acid,p-coumaric acid, and gallic acid.β-Cryptoxanthin, lycopene,β-carotene, zeaxanthin, and lutein are important carotenoids having antioxidant potential. They are important to prevent oxidation of low-density lipoproteins, safeguard beta cells of the pancreas, and reduce cardiovascular diseases, cancer, diabetes mellitus, and damage caused by chronic alcohol consumption. In this paper, the chemistry and health benefits of bioactive compounds present in persimmon are reviewed to encourage impending applications and to facilitate further research activities.

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The current study was based on evaluation of the therapeutic potential (antimicrobial and antidiabetic) of a synbiotic fermented milk product developed by optimising levels of the prebiotic ingredients (fructooligosaccharide and isomaltooligosaccharide). The maximum growth rate (0.27 ± 0.21a cfu/mL) of Lactobacillus acidophilus ATCC® 4357™ was observed with 2.345–2.445% of fructooligosaccharide and 2.53–2.62% of isomaltooligosaccharide. Significant antimicrobial potential of the synbiotic fermented milk was observed against Escherichia coli and Staphylococcus aureus due to the addition of prebiotics. Similarly, the final product also showed 62.9%, 71.5% and 57.0% reduction in blood glucose, urea and creatinine levels, respectively, of diabetic rabbits, when supplemented with 6% of the synbiotic fermented milk. A synbiotic fermented milk product with significant therapeutic potential could be developed using fructooligosaccharide and isomaltooligosaccharide as prebiotic ingredients.

The hypolipidaemic effects of synbiotic yoghurt prepared by Lactobacillus acidophilus, fructooligosaccharide (FOS) and isomaltooligosaccharide (IMOS) were accessed through biological study. Hyperlipidaemia-induced rabbits were fed on diet containing different levels of synbiotic yoghurt, and the blood of animals was analysed for lipid profile on a weekly basis. There were significant reductions in total cholesterol (124.00 AE 7.10 mg/dL), triglycerides (155.00 AE 8.88 mg/ dL), low-density lipoprotein levels (13.27 AE 0.76 mg/dL) and very low-density lipoprotein levels (57.04 AE 3.27 mg/dL), whereas high-density lipoprotein levels (53.70 AE 0.35 mg/dL) were increased. On the basis of these results, it was concluded that the synbiotic yoghurt possessed a significant hypolipidaemic potential.