Introduction: Mucormycosis is an opportunistic angio-fungal infection that has resurfaced during the COVID-19 pandemic period due to multifarious reasons. Due to the limitations of current interventions associated with it, prevention is the recommended strategy. Ayurveda has a significant role to play in prevention, for which prior understanding of the condition in its own parlance is essential. Materials and Methods: Literature and research works from Ayurveda and Western biomedicine relevant to the subject were identified, screened, explored, and interpreted. The data obtained were grouped into three major criteria: etiological factors, disease patterns, and disease targets. These ideas were grouped to obtain a near-total picture of mucormycosis. A set of recommendations, including diet, regimen, single drugs, formulations, therapeutic procedures, and community-level interventions, were made on the basis of research evidence and textual indications. Results and Discussion: Mucormycosis is an exogenous condition that initially follows a common pathogenetic pattern, localizing at various sites to show diverging manifestations. Kapha and Pitta (especially in terms of Snigdha and Uṣna properties) play a major role in preventive and curative strategies in terms of food, regimen, medicine, and therapies. Conclusion: The current Ayurveda knowledge should be effectively used in diagnosing, staging, preventing, and rehabilitating the cases of mucormycoses. Their curative role as adjuvant and standalone therapies are to be subjected to further research.