No abstract

ultrasound scan, uroflow, urinalysis and culture, urine Ca/creatinine, and first-morning urine osmolality. Patients <5 years of age, with secondary enuresis, and those who did not show at the follow-up visit were excluded.Oral desmopressin lyophilisate was recommended to all patients with PMNE and normal bladder capacity. After one month of therapy, initial success was assessed according to ICCS. Correlation coefficients were used to identify variables that were significantly correlated to complete response. ROC analysis was used to determine the urine osmolality cut-off value. Odds ratio and correlation coefficients in favor of complete initial success were analyzed with binary logistic regression.There were 48 patients with PMNE who received desmopressin and were followed for treatment success. Of tested variables, only lower urine osmolality was found to be significantly in favor of complete response to desmopressin therapy. ROC analysis determined the value of £814 mOsm/L as a cut-off value for complete success (sensitivity 65% and specificity 75%). The odds ratio for complete success with desmopressin therapy in PMNE patients with first-morning urine osmolality £814 mOsm/L was 9.086 (95% CI 1.893 -43.618, P = 0.006).For PMNE patients with high pretreatment morning urine osmolality, an alternative treatment to desmopressin should be considered because of the significantly higher risk of treatment failure.