A fundamental problem in hearing is detecting a "target" stimulus (e.g., a friend's voice) that is presented with a noisy background (e.g., the din of a crowded restaurant). Despite its importance to hearing, a relationship between spiking activity and behavioral performance during such a "detection-in-noise" task has yet to be fully elucidated. In this study, we recorded spiking activity in primary auditory cortex (A1) while rhesus monkeys detected a target stimulus that was presented with a noise background. Although some neurons were modulated, the response of the typical A1 neuron was not modulated by the stimulus- and task-related parameters of our task. In contrast, we found more robust representations of these parameters in population-level activity: small populations of neurons matched the monkeys' behavioral sensitivity. Overall, these findings are consistent with the hypothesis that the sensory evidence, which is needed to solve such detection-in-noise tasks, is represented in population-level A1 activity and may be available to be read out by downstream neurons that are involved in mediating this task. This study examines the contribution of A1 to detecting a sound that is presented with a noisy background. We found that population-level A1 activity, but not single neurons, could provide the evidence needed to make this perceptual decision.

The full neural circuits of conscious perception remain unknown. Using a visual perception task, we directly recorded a subcortical thalamic awareness potential (TAP). We also developed a unique paradigm to classify perceived versus not perceived stimuli using eye measurements to remove confounding signals related to reporting on conscious experiences. Using fMRI, we discovered three major brain networks driving conscious visual perception independent of report: first, increases in signal detection regions in visual, fusiform cortex, and frontal eye fields; and in arousal/salience networks involving midbrain, thalamus, nucleus accumbens, anterior cingulate, and anterior insula; second, increases in frontoparietal attention and executive control networks and in the cerebellum; finally, decreases in the default mode network. These results were largely maintained after excluding eye movement-based fMRI changes. Our findings provide evidence that the neurophysiology of consciousness is complex even without overt report, involving multiple cortical and subcortical networks overlapping in space and time.

The advent of cranial implants revolutionized primate neurophysiological research because they allow researchers to stably record neural activity from monkeys during active behavior. Cranial implants have improved over the years since their introduction, but chronic implants still increase the risk for medical complications including bacterial contamination and resultant infection, chronic inflammation, bone and tissue loss and complications related to the use of dental acrylic. These complications can lead to implant failure and early termination of study protocols. In an effort to reduce complications, we describe several refinements that have helped us improve cranial implants and the wellbeing of implanted primates.

Startle reflexes employ specialized neuronal circuits and synaptic features for rapid transmission of information from sense organs to responding muscles. Successful excitation of these pathways requires the coincidence of sensory input at central synaptic contacts with giant fiber targets. Here we describe a pathway feature in the crayfish tailflip reflex: A position-dependent linear gradation in sensory axonal conduction velocities that can ensure the coincident arrival of impulses from near-field hydrodynamic sensilla along the crayfish antennules at their synaptic contacts with central nervous elements that drive startle behavior. This provides a previously unexplored mechanism to ensure optimum responses to sudden threatening stimuli. Preliminary findings indicate that axons supplying distally located sensilla increase their diameters at least ten-fold along the antennular flagella and raise the possibility that more modest, graduated, diameter changes in axons originating from progressively more proximal sensilla along the antennule underlie the observed modifications in axonal conduction velocity.crustacean ͉ sensory receptor ͉ startle reflex ͉ giant axons ͉ hydrodynamic sensilla

Perceptual representations of auditory stimuli (i.e., sounds) are derived from the auditory system’s ability to segregate and group the spectral, temporal, and spatial features of auditory stimuli—a process called “auditory scene analysis”. Psychophysical studies have identified several of the principles and mechanisms that underlie a listener’s ability to segregate and group acoustic stimuli. One important psychophysical task that has illuminated many of these principles and mechanisms is the “streaming” task. Despite the wide use of this task to study psychophysical mechanisms of human audition, no studies have explicitly tested the streaming abilities of non-human animals using the standard methodologies employed in human-audition studies. Here, we trained rhesus macaques to participate in the streaming task using methodologies and controls similar to those presented in previous human studies. Overall, we found that the monkeys’ behavioral reports were qualitatively consistent with those of human listeners, thus suggesting that this task may be a valuable tool for future neurophysiological studies.