BackgroundThe number of people living with HIV (PLHIV) in need of treatment monitoring in low-and-middle-income countries has been rapidly expanding, placing an increasing burden on laboratories. Promising new point-of-care (POC) test have the potential to reduce laboratory workloads, but the implementation cost is uncertain. We sought to estimate the costs of decentralized POC testing compared to centralized laboratory testing for PLHIV initiating treatment in South Africa.MethodsWe conducted a microcosting analyses comparing clinic-based POC testing to centralized laboratory testing for HIV viral load, creatinine, and CD4 count monitoring. We completed time-and-motion studies to assess staff time for sample collection and processing. Instrument costs were estimated assuming five-year lifespans and we applied a 3% annual discount rate. Total costs and cost per patient were estimated over a five-year period: the first year of ART initiation and four years of routine HIV monitoring, following World Health Organization ART monitoring guidelines.ResultsWe estimated that per-patient costs of POC HIV viral load, CD4, and creatinine tests were USD $25, $11, and $9, respectively, assuming a clinic volume of 50 patients initiated per month. At centralized laboratories, per-patient costs of POC HIV viral load, CD4, and creatinine tests were USD $26, $6, $3. Total monitoring costs of all testing over a 5-year period was $45 higher for POC testing compared to centralized laboratory testing ($210 vs $166).ConclusionsPOC testing for HIV care and treatment can be feasibly implemented within clinics in South Africa, particularly those with larger patient volumes. POC HIV viral load costs are similar to lab-based testing while CD4 count and creatinine testing are more costly as POC tests. Our cost estimates are useful to policymakers in planning resource allocation and can inform cost-effectiveness analyses of POC testing.

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As the number of people living with chronic diseases climbs upward, novel methods to address the root causes of these disease are necessary to transform the state of our nation's health and our health care system. Interventions directed at making lasting lifestyle changes can have a major impact on the overall health of patients. In this pilot study, 4 obese patients, with unhealthy habits and abnormal blood profiles and biometrics, were able to significantly improve their lifestyles and their lab values with the 3-month intervention of a lifestyle medicine team, including a physician trained in lifestyle medicine, a certified wellness coach, a licensed nutrition specialist, a physical therapist, and a licensed mental health professional. Two patients had type 2 diabetes, and all 4 were hypertensive (blood pressure > 120/80 mm Hg). After the intervention, all improved their nutrition and increased their physical activity. In addition, all experienced improvements in lipid counts, blood pressure, weight loss, and cholesterol. The diabetic patients' levels of hemoglobin A1C dropped to normal. These successes show the benefits of a lifestyle medicine team approach.