The optimal vascular graft should exhibit sufficient mechanical strength, low immunogenicity, high biocompatibility, and resistance to calcification, thrombosis, stenosis, and infection. 1 From a surgical perspective, it should be easy to handle, have reasonable manufacturing costs, and be readily available. Large diameter vascular grafts (>5 mm luminal diameter) have been successfully developed, but smaller vascular grafts (<5 mm luminal diameter) are difficult to generate because of blood clotting, scarring, or occlusion after implantation. 1 The materials used to construct vascular grafts fall into two categories: synthetic or biologic. 2 Synthetic scaffolds are either made from nondegradable polymers such as polytetrafluoroethylene and Dacron, which are widely used in the clinic, or biodegradable polymers such as poly(lactic-acid) and poly(glycolic-acid). 1,2 Synthetic scaffolds are advantageous with respect to the manufacturing process providing reproducible properties such as mechanical strength, size, and configuration. 1 However, current synthetic models are unable to actively respond to cellular signals and often lack the ability to host cell attachment or growth. 3,4 Biologic scaffolds are