2-tert- 6,7,8,9,indole was synthesized by reaction of cycloheptanone and (4-tert-butylphenyl)hydrazine hydrochloride in the presence of sodium acetate and sulfuric acid in glacial acetic acid via Fischer indole synthesis. . Recently paullone chalcone hybrid structures 1 were reported to inhibit the growth of Leishmania amastigotes in vitro [7]. In order to study structure-activity relationships regarding this antiparasitic activity congeners related to 1 are currently investigated. In the course of these studies we were interested in 2-tert-butyl-5, 6,7,8,9,10-hexahydrocyclohepta[b]indole (2) representing the tert-butyl substituted indole fragment reminiscent of the paullone substructure in 1. A thorough survey of the literature revealed that 2 was hitherto unknown. KeywordsThe synthesis of 2 was accomplished by a straightforward Fischer indole synthesis [8,9] protocol from cycloheptanone (3) and (4-tert-butylphenyl)hydrazine hydrochloride (4). OPEN ACCESS