The benefits of vitamin D supplementation in this population need to be demonstrated before widespread 'test and treat' policies can be recommended as part of routine clinical practice.

Parathyroid hormone (PTH) elevations are associated with reduced bone mineral density and adverse health outcomes and have been reported in patients with HIV infection. We aimed to examine the impact of vitamin D status and tenofovir (TDF) use on PTH levels among HIV-infected patients receiving combination antiretroviral therapy (cART). Demographics, medication and supplement use, and clinical data, including 25-hydroxyvitamin D [25(OH)D] and PTH, were collected on 45 HIV-infected men on ART. Suboptimal vitamin D status was defined as 25(OH)D < 30 ng/ml. The relationship between antiretroviral agents, suboptimal 25(OH)D, and PTH levels was examined. Among subjects with suboptimal vitamin D status, PTH values greater than or equal to the ULN (87 pg/ml) were more common among TDF users than nonusers: 41% versus 0% ( p ¼ 0.018); and median PTH was higher in TDF users: 80 pg/ml versus 55 pg/ml ( p ¼ 0.02). Among TDF users, PTH was higher in the group with suboptimal 25(OH)D ( p ¼ 0.045). Multivariable linear regression showed that PTH was independently and directly related to TDF use ( p ¼ 0.017) and inversely related to 25(OH)D ( p ¼ 0.017). PTH was not related to the estimated glomerular filtration rate ( p ¼ 0.9). In this cross-sectional study of HIV-infected men on ART, the use of TDF and the level of 25(OH)D were independently associated with PTH levels. Because TDF is a potent and widely used antiretroviral drug, information about cofactors that may exacerbate its side effects is of significant clinical value.

For millennia, people have used narratives to inform and persuade. However, little social psychological research addresses how and when narrative persuasion occurs, perhaps because narratives are complex stimuli that are difficult to vary without significantly changing the plot or characters. Existing research suggests that regulatory fit and/or processing fluency can be varied easily and in ways completely exterior to narrative content but that nonetheless affect how much narratives engage, transport, and persuade. We review research on narrative transportation and persuasion and then discuss regulatory fit and its relationship to processing fluency. Afterward, we discuss how regulatory fit and processing fluency may affect psychological engagement, transportation, and persuasion via narratives.