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preterm vs. term birth in the index twin pregnancy. The analysis was further stratified by gestational age at birth, indication for PTB and chorionicity in the index twin pregnancy. Unadjusted odds ratios and confidence intervals were calculated for each of the objectives. RESULTS: A total of 378 women met the study inclusion criteria, of whom 252 (66.7%) had PTB in the index twin pregnancy. The overall rate of PTB in the subsequent singleton pregnancy was 11.6% (44/378) and was significantly higher for women with prior twin PTB compared with women with prior term twin birth (17.5% vs. 6.3%, p¼ 0.003, OR 3.12, 95%-CI 1.42-6.85). The risk of PTB in the subsequent singleton pregnancy was related to the degree of prematurity in the index twin delivery (Figure). The association between previous twin PTB and subsequent singleton PTB was significant only for cases of prior spontaneous twin PTB (OR 3.27, 95%-CI 1.47-7.27) but not for cases of prior indicated twin PTB (OR 2.52, 95%-CI 0.86-7.38). Chorionicity in the index twin delivery did not affect the relationship between prior twin PTB and risk of future singleton PTB. CONCLUSION: History of preterm twin birth is associated with higher odds of subsequent preterm singleton birth, and the risk is related to the severity of prematurity in the index twin PTB.

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RESULTS: 316 women were included. Hispanics were disproportionally affected by COVID19 (Table 1). Of 60 COVID+ women, 33 (55%) women had positive RT-PCR, most with mild symptoms, and 53 (88%) women had positive IgG near delivery. There were no cases of short cervix in the positive group. The data suggest a higher rate of PPROM in the positive group but after controlling for confounders, our numbers were too small to confirm this difference (aOR 2.34, 95% CI 0.84-6.46) (Table 2). Similarly, there was no difference in sPTB rates between the groups (aOR 1.35, 95% CI 0.48-3.75). Further, there was no difference in sPTB relative to the same time period in 2019 (2.9% vs 3.1%, p¼0.68). CONCLUSION: In our cohort, COVID19 RT-PCR or IgG positive patients had a similar to slightly increased odds of cervical shortening, sPTB, and PPROM compared to negative patients.

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