Background: LRP1 is an endocytic receptor of ADAMTS-5 (aggrecanase 2) in cartilage. Results: ADAMTS-4 (aggrecanase 1) is also internalized via LRP1 but at a slower rate than ADAMTS-5. Conclusion: LRP1 differently regulates the extracellular activities of the two key aggrecanases in cartilage. Significance: LRP1 is a major traffic controller of the two aggrecanases.
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