Music affects performance in both sensory and motor tasks. It can also provide a significant form of therapy for some mental illness, particularly anxiety. This study investigated the effects of music on anxiety between: (1) music and nonmusic majors; (2) females and males of each group; and (3) females and males, regardless of sex, to determine the combined interaction effect. Results showed that there were significant differences in responses between each of the stated groups. Moreover, the female responses to music were more consistent than the male responses in all groups.