Objective-To review the research literature on the parental experience of pregnancy, primarily maternal, subsequent to perinatal loss. Data Sources-Computerized searches on CINAHL and PubMed databases.Study Selection-Articles from indexed journals relevant to the objective were reviewed from January 1997 to December 2007. Only research-based studies in English were included.Data Extraction-The review was performed using the methodology of Whittemore and Knafl (2005). Data were extracted and organized under headings: author/year/setting; purpose; sample; design/instruments; results; and nursing implications for parents during a pregnancy following a perinatal loss.Data Synthesis-Depression and anxiety are frequently seen in pregnant women subsequent to a perinatal loss. The parental experience is filled with intense and conflicting emotions as parents balance being hopeful while worrying about another potential loss.