Estrogens, such as estrone, estradiol and estriol, were tested as possible antioxidants of lipid peroxidation induced by Fe3+-ADP-adriamycin or Fe 3+-ADP-ascorbate. The estrogens with phenolic structure possessed substantial activities with respect to the inhibition of lipid peroxidation. Concentrations of estradiol and estriol required to achieve 50% inhibition of membrane phospholipid peroxidation were about 4-and 6-times that of a-tocopherol, respectively

No abstract

No abstract

No abstract

When a Cypridina luciferin analog (the title compound) was added to a macrophage suspension in Hank's balanced salt solution (control), the system emitted a weak, but detectable light, which was not altered in the presence of Superoxide dismutase. The same system, however, emitted a much stronger light, just after the addition of a trigger, opsonized zymosan. The luminescence was suppressed to the control level in the presence of superoxide dismutase, while it was only slightly influenced, if at all, by NaN3, a scavenger of singlet oxygen and an inhibitor of myeloperoxidase. Some other results obtained also indicate the participation of O2 − in the luciferin analog‐dependent luminescence in macrophages during phagocytosis.