ABSTRACT. A 33-year-old Japanese woman had bilateral eyelid swelling and soft tumor of the right orbit. Increased serum IgE and eosinophilia in the peripheral blood was observed. Magnetic resonance imaging of the lesion showed hypointense orbital fat on T1-weighted image and isointense orbital fat on T2-weighted image. Gd-DTPA T1-weighted images demonstrated marked enhancement. The histopathological appearance of the tumor was consistent with Kimura's disease. On a regimen of 60 mg of prednisone per day, the orbital mass reduced in size. A review of the recent literature indicated that corticosteroids rather than surgery might be tried at least initially as treatment.

We examined refractions of 102 eyes in 51 Japanese children after the topical instillation of cycloplegics. Cyclopentolate 1% was instilled 3 times after 5-min intervals, and refractions were evaluated 45 min after the last instillation. Atropine, 0.5% or 1%, was instilled twice daily for 7 days. Refractions were measured by an autorefractometer. The mean refraction in 102 eyes measured after atropine instillation was +3.07 dpt, and the mean after cyclopentolate instillation was +2.35 dpt. The mean difference in the direction of meridians of maximal refractions measured after atropine and cyclopentolate was 22°. Our findings showed that atropine instillation may be adequate to determine exact refractions in Japanese children.

We reviewed retrospectively the charts of 36 patients (72 eyes) with BehÇet’s disease. The visual acuities in 21 patients receiving colchicine (group A) gradually decreased with time. The visual acuities in 9 patients receiving colchicine and systemic corticosteroid (group B) gradually decreased after the onset of the disease and were significantly worse than those in group A 10 and 15 years after onset. The visual acuities in 6 patients receiving colchicine and cyclosporin (group C) gradually decreased, and their visual acuity scores were similar to those in group A.

Careful consideration is required in the assessment of cell proliferation using PCNA. The immunostaining of Ki-67 may be more accurate than that of PCNA for evaluating cell proliferation in formalin-fixed, paraffin-embedded tissues.