The present work involves the synthesis of Benzothiazole capped triazole‐silane (3) by ‘Click Silylation’ and its immobilization onto silica surface. This new silane is characterised by IR, 1H, 13C spectroscopy. TGA, TEM and SEM were the evidence for its adsorption at silica surface. The anti‐parasitic, anti bacterial and anti oxidant activity of synthesised compounds was evaluated. The results shows that nanoparticle of silane displayed more significant activity as compared to benzothiazole derived silane (3) against G. lamblia, T. vaginalis, various bacterial strains (E.coli, Bacillus subtillus, Staphylococcus aureus, Vibrio cholera) and showed potential anti‐oxidant activity. Further Molecular docking study was performed to analyse the binding manner and enzyme inhibitory activity of compound‐3 with β‐glucuronidase.

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This work describes the study of photophysical properties of triazolelinked benzothiazole based Silane (K3) and its nanoparticles (K3‐NPs). Interestingly, both K3 and K3‐NPs exhibited highly selective chemo‐sensing ablility for Cu2+ ions. The significance of N, S and triazole group in synthesized compounds for Cu2+ sensing has been confirmed by structure‐property studies. Concentration dependent colorimetric metal sensing studies indicate that Cu2+ can be detected up to 10 μM. DFT studies, colorimetric analysis, Cyclic Voltametry, absorption and emission spectroscopy techniques helped us to evaluate efficiency towards amino acids along with copper complexation.

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