No abstract

Activation/functionalization of inert C-H bond has undergone rapid growth in last decade and provides novel retro-synthetic disconnections for the synthesis of valuable molecules. The selectivity is often achieved by the use of directing group and is mainly limited to the proximal C-H bond. Initially, meta C-H activations were based on electronic or steric control and now it can be achieved by employing nitrile-based end-on-template as the directing group. The compilation of the remote C-H activation strategy will provide the useful linkage to the scientific community. This article is focused on recent progress in remote C-H activation, mechanistic understanding, and its applications in the field of total synthesis of targeted molecules.

In the current time, the development of new synthetic strategies, capable of enabling step efficiency and atom economy by utilizing easily accessible starting materials is highly desirable. In this regard, the C-H activation protocol is one of the most promising approaches. The synthesis of heterocyclic moieties via a C-H activation protocol starting from easy-to-handle, readily accessible starting materials is extremely important and desirable. Olefins are generally considered as chemical feedstock for the synthesis of various valuable products due to their wide availability. Although unactivated olefins are easy to handle, due to their unbiased nature achieving total regioselectivity remains a challenge.

Proximity -[recent progress in remote C-H activation, mechanistic understanding, and its ap plication; 145 refs.]. -(SHARMA, R.; THAKUR, K.; KUMAR, R.; KUMAR, I.; SHARMA, U.; Catal. Rev.: Sci. Eng. 57 (2015) 3, 345-405, http://dx.

Olefins as Unprecedented Feedstock for the Synthesis of Valuable Heterocycles: Regioselectivity Remains an Issue -[8 refs.]. -(THAKUR, K.; SHARMA, R.; SHARMA*, U.; Synlett 26 (2015) 2, 137-141, http://dx.doi.org/10.1055/s-0034-1379707 ; Div. Nat. Prod. Chem. Process Dev., Inst. Himalayan Bioresour. Technol., Palampur 176 061, India; Eng.) -Y. Steudel 15-307