Objectives This paper proposed the neural network-based segmentation model using Pre-trained Mask Convolutional Neural Network (CNN) with VGG-19 architecture. Since ovarian is very tiny tissue, it needs to be segmented with higher accuracy from the annotated image of ovary images collected in dataset. This model is proposed to predict and suppress the illness early and to correctly diagnose it, helping the doctor save the patient's life. Methods The paper uses the neural network based segmentation using Pre-trained Mask CNN integrated with VGG-19 NN architecture for CNN to enhance the ovarian cancer prediction and diagnosis. Results Proposed segmentation using hybrid neural network of CNN will provide higher accuracy when compared with logistic regression, Gaussian naïve Bayes, and random Forest and Support Vector Machine (SVM) classifiers.