Introduction: Chronic periodontitis is an infectious disease resulting in inflammation within the supporting tissues of the teeth, progressive attachment loss and bone loss. Non-surgical periodontal treatment of chronic periodontitis poses a great challenge. Conventional treatment includes Scaling and Root Planing (SRP) and mechanical debridement. Studies have suggested use of ozonated olive oil for management of periodontal infection. Objective: The aim of this study was to evaluate the effect of using Ozonated olive oil along with SRP, compared to subgingival chlorhexidine with SRP for treatment of chronic periodontitis. Materials and Methods: In this split-mouth design, twenty untreated chronic periodontitis patients who met the criteria of having periodontal pocket with depth ≥4mm and bleeding on probing (BOP) in at least two different quadrants were included. Group 1 (control) subgingival chlorhexidine application was done and in group 2 (test) ozonated olive oil application with SRP was done. Clinical parameters were evaluated at baseline, 7 days, 14 days and 21 days post treatment and plaque samples at baseline and 21 days. Microbiological analysis was done to assess the change in level of P. gingivalis. Result: Both the groups (test & control) showed improvement in all the recorded parameters (PI, GI, PPD& microbiological analysis) while the test group showed statistically significant reduction in all the clinical parameters compared to control group (p < 0.05)except the microbiological analysis. Conclusion:A single subgingival irrigation with ozonated oil can be effectively used as an adjunct to SRP in non-surgical management of chronic periodontitis.

No abstract