BackgroundCardiovascular diseases represent a major contributor to the increased mortality. Risk factors varies according to the subtypes of cardiovascular events and perhaps racial background. Little is known about the risk of major cardiovascular events (MACE) in Saudi lupus Population.ObjectivesThis study aim to examine the prevalence of MACE among Saudi SLE compared to general population and factors associated with such outcome.MethodsThis a cross-sectional study nested within two prospective cohorts to assess the period prevalence of any MACE among SLE patients who were enrolled in national prospective cohort of SLE, Saudi Arabia since its initiation in 2020. As a comparison, Prospective Urban Rural Epidemiology Study Saudi sub-cohort (PURE-Saudi) for participants who have been enrolled during the same follow up period. Participants in both studies were followed using standardized published protocol. MACE was defined as the diagnosis of Myocardial infraction, stroke or Angina. We adjust for demographics, traditional cardiovascular risk factors and the diagnosis of SLE using logistic regression models.ResultsA total of 488 with SLE and 746 from PURE were included. SLE patients were younger (40.7±12.5 compared to 49.5±8.6) and female predominant (90.6% compared to.41.6%). Prevalence of traditional risk factors were less in SLE patients including dyslipidemia (28.9% compared to 49.4%), obesity (63% compared to 85%) diabetes (7.8% compared to 27.2%) but not HTN (19.3 compared to 18.8%). Odds of MACE were significantly related to Age and Lupus diagnosis (OR: 1.08, 95% CI: 1.04-1.11, p=0.00) and (OR: 7.64, 95% CI: 2.65-22.07, p=0.00) but not CVS risk factors (OR: 0.8, 95% CI: 0.10-6.39, p=0.83).ConclusionSLE patients at significant risk of MACE compared to general population. This risk is not well explained by traditional risk factors which may explain the failure of CVS risk scores to adequately stratify SLE patients. Further work is needed to understand the pathogenesis of CVS risk in SLE and subsequently mitigate it.References[1]Yurkovich M, Vostretsova K, Chen W, Avina-Zubieta JA. Overall and cause-specific mortality in patients with systemic lupus erythematosus: a meta-analysis of observational studies. Arthritis care & research. 2014;66(4):608-616.[2]Rees F, Doherty M, Grainge MJ, Lanyon P, Davenport G, Zhang W. Mortality in systemic lupus erythematosus in the United Kingdom 1999–2012. Rheumatology. 2016;55(5):854-860.[3]Falasinnu T, Chaichian Y, Li J, et al. Does SLE widen or narrow race/ethnic disparities in the risk of five co-morbid conditions? Evidence from a community-based outpatient care system. Lupus. 2019;28(14):1619-1627.Acknowledgements:NIL.Disclosure of InterestsNone Declared.

Introduction: The presence of tissue damage in the lungs, kidneys, heart, or other organs can be detected by monitoring the level of Lactate Dehydrogenase (LDH) in the blood and considered a reliable biomarker in early prediction of patients’ prognosis. Aim: To determine extent of correlation between LDH level with the spectrum and in-hospital outcome of Coronavirus Disease2019 (COVID-19) infected patients. Materials and Methods: This retrospective research was undertaken during March 2020 to May 2020, based on the data of 205 COVID-19 infected patients, reported at Dammam Medical Complex, Dammam, Eastern Province, Saudi Arabia. Patients’ records were retrieved and the following data were recorded-age, gender, nationality, co-morbidities, lactate dehydrogenase level, number of days since the patient tested positive (Up to 7,14 and >14 days), COVID-19 symptoms [mild, moderate, or severe as per British Thoracic Society guidelines (CURB (Confusion, Blood Urea Nitrogen, Respiratory Rate, Blood Pressure)-65)]. The data was collected and tabulated as mean±SD, frequency and percentages. Analysis was carried out using specialized software of Statistical Package for Social Sciences (SPSS) version 20.0. Results: On analysis of the collected data of all 205 included patients, the LDH level was found significantly high among males, 46-60 years old, and among non-Saudi patients. The severity of COVID-19 symptoms and LDH levels were found to have a strong relationship (p-value<0.001). Patients between the ages of 46 and 60 were more likely (4.3 times) to have poor outcomes, and diabetes mellitus was predicted to be 2.32 times more likely to be associated with poor COVID-19 outcomes. Raised LDH levels were >5 times more likely to lead to in-hospital poor outcomes compared to those with borderline LDH levels. Conclusion: LDH level is a reliable predictor for the cause of COVID-19. The results of the present study suggest that patients aged 46-60 years, diabetic patients, or those suffering from severe symptoms of COVID-19 have raised levels of LDH.

Introduction: The presence of tissue damage in the lungs, kidneys, heart, or other organs can be detected by monitoring the level of Lactate Dehydrogenase (LDH) in the blood and considered a reliable biomarker in early prediction of patients’ prognosis. Aim: To determine extent of correlation between LDH level with the spectrum and in-hospital outcome of Coronavirus Disease2019 (COVID-19) infected patients. Materials and Methods: This retrospective research was undertaken during March 2020 to May 2020, based on the data of 205 COVID-19 infected patients, reported at Dammam Medical Complex, Dammam, Eastern Province, Saudi Arabia. Patients’ records were retrieved and the following data were recorded-age, gender, nationality, co-morbidities, lactate dehydrogenase level, number of days since the patient tested positive (Up to 7,14 and >14 days), COVID-19 symptoms [mild, moderate, or severe as per British Thoracic Society guidelines (CURB (Confusion, Blood Urea Nitrogen, Respiratory Rate, Blood Pressure)-65)]. The data was collected and tabulated as mean±SD, frequency and percentages. Analysis was carried out using specialized software of Statistical Package for Social Sciences (SPSS) version 20.0. Results: On analysis of the collected data of all 205 included patients, the LDH level was found significantly high among males, 46-60 years old, and among non-Saudi patients. The severity of COVID-19 symptoms and LDH levels were found to have a strong relationship (p-value<0.001). Patients between the ages of 46 and 60 were more likely (4.3 times) to have poor outcomes, and diabetes mellitus was predicted to be 2.32 times more likely to be associated with poor COVID-19 outcomes. Raised LDH levels were >5 times more likely to lead to in-hospital poor outcomes compared to those with borderline LDH levels. Conclusion: LDH level is a reliable predictor for the cause of COVID-19. The results of the present study suggest that patients aged 46-60 years, diabetic patients, or those suffering from severe symptoms of COVID-19 have raised levels of LDH.