Another possibility is that the Ts16 neurons are developmentally immature relative to diploid neurons and that the rapidity of infection is a function of developmental maturity. Neonatal mice inoculated with scrapie prions intraperitoneally but not intracerebrally exhibited a prolongation of their incubation period {GI. Recently, there have been reports of successful treatment of SSPE with systemic 141, intrathecal 157, or intraventricular {b} administration of human interferon From the

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