Mental disorders (MDs), including schizophrenia (SCZ) and bipolar disorder (BD), have attracted special attention from scientists due to their high prevalence and significantly debilitating clinical features. The diagnosis of MDs is still essentially based on clinical interviews, and intensive efforts to introduce biochemical based diagnostic methods have faced several difficulties for implementation in clinics, due to the complexity and still limited knowledge in MDs. In this context, aiming for improving the knowledge in etiology and pathophysiology, many authors have reported several alterations in metabolites in MDs and other brain diseases. After potentially fishing all metabolite biomarkers reported up to now for SCZ and BD, we investigated here the proteins related to these metabolites in order to construct a protein–protein interaction (PPI) network associated with these diseases. We determined the statistically significant clusters in this PPI network and, based on these clusters, we identified 28 significant pathways for SCZ and BDs that essentially compose three groups representing three major systems, namely stress response, energy and neuron systems. By characterizing new pathways with potential to innovate the diagnosis and treatment of psychiatric diseases, the present data may also contribute to the proposal of new intervention for the treatment of still unmet aspects in MDs.

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In our life, music is a vital entertainment part whose important elements are musical instruments. Forexample, the acoustic drum plays a vital role when a song is sung. With the modern era, the style of themusical instruments is changing by keeping identical tune such as an electronic drum. In this work, wehave developed "Virtual Musical Drums" by the combination of MEMS 3D accelerometer sensor data and machine learning. Machine learning is spreading in all arena of AI for problem-solving and the MEMS sensor is converting the large physical system to a smaller system. In this work, we have designed eight virtual drums for two sensors. We have found a 91.42% detection accuracy within the simulation environment and an 88.20% detection accuracy within the real-time environment with 20% windows overlapping. Although system detection accuracy satisfaction but the virtual drum sound was nonrealistic. Therefore, we implemented a 'multiple hit detection within a fixed interval, sound intensity calibration and sound tune parallel processing' and select 'virtual musical drums sound files' based on acoustic drum sound pattern and duration. Finally, we completed our "Playing Virtual Musical Drums" and played the virtual drum successfully like an acoustic drum. This work has shown a different application of MEMS sensor and machine learning. It shows a different application of data, sensor and machine learning as music entertainment with high accuracy.