The present study examined the inhibitory eects of N-Hydroxy-N'-(4-butyl-2-methylphenyl)-formamidine (HET0016) on the renal metabolism of arachidonic acid by cytochrome P450 (CYP) enzymes. HET0016 exhibited a high degree of selectivity in inhibiting the formation of 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) in rat renal microsomes. The IC 50 value averaged 35+4 nM, whereas the IC 50 value for inhibition of the formation of epoxyeicosatrienoic acids by HET0016 averaged 2800+300 nM. In human renal microsomes, HET0016 potently inhibited the formation of 20-HETE with an IC 50 value of 8.9+2.7 nM. Higher concentrations of HET0016 also inhibited the CYP2C9, CYP2D6 and CYP3A4-catalysed substrates oxidation with IC 50 values of 3300, 83,900 and 71,000 nM. The IC 50 value for HET0016 on cyclo-oxygenase activity was 2300 nM. These results indicate that HET0016 is a potent and selective inhibitor of CYP enzymes responsible for the formation of 20-HETE in man and rat.

The less distensible carotid wall in patients with KD compared with that in Cont without major alteration of the lipid profile is likely to be secondary to the changes in arterial walls after a diffuse vasculitis involving noncoronary arteries. These results indicate that the coronary arteries may be predisposed to accelerated atherosclerosis in patients with KD and CAL.

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In order to understand the behavior of COS in a ZnO desulfurization reactor, the reaction between ZnO and COS was studied in the presence of gases which compose a coal-derived gas. The behavior of COS in the reaction zone of a ZnO packed bed can be predicted as follows:  H2S in coal-derived gas reacts more easily with ZnO than COS; most of COS is converted to H2S by catalytic hydrolysis and then reacts with ZnO, although a part of COS may react directly with ZnO; H2 accelerates the conversion of COS to H2S; the water−gas shift reaction accelerates the reaction between ZnO and COS; and CO2 does not affect the reaction.

Statistical AnalysisAll numeric data are presented as the means ± SD. Because of differences in the variables and limited sample numbers, statistic analysis was performed using Wilcoxon nonparametric analysis or chi-square analysis when necessary. A p-value less than 0.05 was considered significant. Circ J 2007; 71: 1606 -1609 (Received May 8, 2007 revised manuscript received June 14, 2007; accepted June 22, 2007 Background This study was performed to investigate the frequency and importance of supraventricular arrhythmia and sinus node (SN) dysfunction in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT). Methods and ResultsEight patients with CPVT (mean age: 16.8±8.1 years) underwent an electrophysiological study. SN recovery time (1,389±394 ms) was slightly prolonged, and 4 of 8 patients had abnormal values. Atrial flutter (AF) was induced by low-rate atrial pacing in 2 patients and by isoproterenol infusion in 1 patient. Atrial fibrillation (Af) was induced by isoproterenol infusion in 2 patients. One patient presented with Af during the follow-up period, and 2 of 4 patients with AF/Af presented with increased SN recovery time.Conclusions Patients with CPVT frequently have associated with SN dysfunction, and inducible atrial tachyarrhythmias, which indicate that the pathogenesis of CPVT is limited not only to the ventricular myocardium, but also to broad regions of the heart, including the SN and atrial muscle. (Circ J 2007; 71: 1606 -1609)