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Intercellular adhesion molecule 1 (ICAM-1) plays an important role in the pathogenesis of insulin-dependent diabetes mellitus (IDDM) by being involved in the extravasation of lymphocytes from the circulation into the inflamed pancreas. However, the mechanism of beta-cell destruction by which expression of ICAM-1 on beta-cells may facilitate adhesion of effector cells still remains to be elucidated. Several lines of evidence suggest that this adhesion molecule is involved in the destruction of pancreatic beta-cells by killer lymphocytes in the NOD mouse, which shows an autoimmune diabetic syndrome similar to that of human IDDM. Immunohistochemical study under light microscopy demonstrated that all of the mononuclear cells infiltrating the islets strongly expressed ICAM-1 and leukocyte function-associated antigen 1 (LFA-1), a counterreceptor of ICAM-1, whereas ICAM-1 expression on islet cells was not apparent. However, immunohistochemical staining under electron microscopy revealed that islet beta-cells adjacent to infiltrating lymphocytes were clearly stained by an anti-ICAM-1 monoclonal antibody (mAb). Flow cytometric analysis showed that the ICAM-1 expression on NOD islet cells and NOD-derived insulinoma cells (MIN6N8a) was inducible by interferon (IFN)-gamma or tumor necrosis factor-alpha. These cytokines had an additive effect on the ICAM-1 induction. Susceptibility of MIN6N8a cells to lysis by a NOD islet-derived CD8+ cytotoxic T-cell clone was greatly enhanced by IFN-gamma pretreatment, and this enhancement was abolished by anti-ICAM-1 and anti-LFA-1 mAbs. When both mAbs were administered into NOD mice with spontaneous or adoptively transferred diabetes, the development of diabetes was significantly prevented.(ABSTRACT TRUNCATED AT 250 WORDS)

With the proliferation of new wireless service, scarce wireless resources is expected to become a critical issue. For this reason, cognitive radio mobile ad hoc networks (CogMANET) are being developed as a promising solution to this problem. However, in CogMANET, channel switching is inherently necessary whenever a primary user with a license appears on the channel. Allowing secondary users to choose an available channel from among a wide spectrum range thus enables reliable communication in this context, but communication characteristics such as bottleneck bandwidth and RTT will change with channel switch. In response to this change, TCP has to adaptively update its congestion window (cwnd) to make an efficient use of the available resources. For this purpose, TCP CRAHN was proposed for CogMANET. In this paper, TCP CRAHN is first evaluated in cases where bottleneck bandwidth and RTT drastically change. Based on these results, TCP CoBA is proposed to further improve the throughput of the above use cases. TCP CoBA updates the cwnd based upon the available buffer space in the relay node upon channel switch, as well as other communication characteristics. Through simulations, we show that compared with TCP CRAHN, TCP CoBA improves the throughput by up to 200%.

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