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Using X-ray free-electron lasers (XFELs), it is possible to determine three-dimensional structures of nanoscale particles using single-particle imaging methods. Classification algorithms are needed to sort out the single-particle diffraction patterns from the large amount of XFEL experimental data. However, different methods often yield inconsistent results. This study compared the performance of three classification algorithms: convolutional neural network, graph cut and diffusion map manifold embedding methods. The identified single-particle diffraction data of the PR772 virus particles were assembled in the three-dimensional Fourier space for real-space model reconstruction. The comparison showed that these three classification methods lead to different datasets and subsequently result in different electron density maps of the reconstructed models. Interestingly, the common dataset selected by these three methods improved the quality of the merged diffraction volume, as well as the resolutions of the reconstructed maps.

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We propose an effective framework for multi-phase image segmentation and semi-supervised data clustering by introducing a novel region force term into the Potts model. Assume the probability that a pixel or a data point belongs to each class is known a priori. We show that the corresponding indicator function obeys the Bernoulli distribution and the new region force function can be computed as the negative log-likelihood function under the Bernoulli distribution. We solve the Potts model by the primal-dual hybrid gradient method and the augmented Lagrangian method, which are based on two different dual problems of the same primal problem. Empirical evaluations of the Potts model with the new region force function on benchmark problems show that it is competitive with existing variational methods in both image segmentation and semisupervised data clustering.

Background: Long QT syndrome (LQTS) is a cardiac disorder characterized by prolonged QT intervals on electrocardiograms (ECG), ventricular arrhythmias, and sudden death. Clinically, two inherited forms of LQTS have been defined: autosomal dominant LQTS or Romano-Ward syndrome (RWS) not associated with deafness and autosomal recessive LQTS or Jervell and Lange-Nielsen syndrome (JLNS) associated with deafness.