The purpose of the study was to examine psychosocial and personal level circumstances associated with ART non-adherence among HIV positive ART user clients in Debre Birhan referral hospital. This study used cross-sectional descriptive design. A total of 122 participants were selected through simple random and purposive sampling techniques. Adherence Attitude Inventory Scale and self-reported adherence questionnaire were administered. The result of chi square analysis revealed that social support, personal self-efficacy, age, marital status, religion, educational level and occupation had significant association with non-adherence at 95% CI, 6.371 (2, N =117) = 0.006, p< 0.05), 11.873 (2,N =117) = 0.012, p< 0.05), (x2) 5.630 (6,N =117) = 0.003, p< 0.05), 0.017 (6, N =117) =0.014, p< 0.05) and 14.497(6,=N=117) = 0.025, p< 0.05. No significant sex difference was observed in attitude towards ART adherence. Besides, the result of multiple regression also showed that only single, unemployment and vocational education were accounted for non- adherence to ART (β = .228, t (113) = 2.655, P< 0.05), (β = .297, t (114) = 3.451, p< 0.05) and ( β = .231, t (113) = 2.652, p< 0.05) respectively. Conclusively, Personal level factors; marital status (singlehood), unemployment and vocational education accounted for variance in adherence to ART. Thus, Counselors, social workers and health care providers should give adherence counseling and psycho education.
