We report an interesting case of chronic endophthalmitis presenting as bilateral retinitis with chronic granulomatous inflammation due to Mycobacterium abscessus in a 17-year-old human immunodeficiency virus (HIV)-positive young male. The diagnosis was made on the basis of cytopathology, culture, and genomic sequencing on the vitreous biopsy. The treatment included antitubercular therapy, intravenous meropenem, and intravitreal amikacin injections. At the end of 6 months, the retinitis resolved well and best-corrected visual acuity (BCVA) was 6/9 both eyes (OU). Though endophthalmitis due to M. abscessus has been described in the literature, bilateral retinitis is rare and is being described in this case report.
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