Aim
Individuals at clinical high risk for psychosis (CHR) exhibit neurocognitive deficits in multiple domains. The aim of this study is to investigate whether several components of neurocognition are predictive of conversion to psychosis.
Methods
Fifty-two CHR individuals were assessed with the Structured Interview for Psychosis Risk Syndromes and completed a battery of neurocognitive tests at baseline including measures of executive functioning, attention, working memory, processing speed, and reaction time. Neurocognitive functioning at baseline was scored based on an external normative control group. Most subjects were followed for 2.5 years to determine conversion status.
Results
Significant differences in neurocognitive functioning between CHR individuals and the control group were present in all domains. Twenty-six percent of the participants converted to psychosis within 9.8 (standard deviation=8.0) months on average (median 9 months), but there were no significant differences in neurocognition converters and non-converters.
Conclusions
Individuals at CHR have deficits in neurocognitive functioning, but such deficits do not appear to be related to conversion risk.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.