Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can lead to acute respiratory distress syndrome (ARDS), multi-organ failure and death, posing significant threat to human health. Studies have found that pathological mechanisms, such as cytokine storms caused by uncontrolled innate immune system activation, release of damage-associated molecular patterns during tissue injury and a high incidence of thrombotic events, are associated with the function and dysfunction of neutrophils. Specifically, the increased formation of low-density neutrophils (LDNs) and neutrophil extracellular traps (NETs) has been shown to be closely linked with the severity and poor prognosis in patients with COVID-19. Our work focuses on understanding the increased number, abnormal activation, lung tissue infiltration, and elevated neutrophil-to-lymphocyte ratio in the pathogenesis of COVID-19. We also explore the involvement of NETs and LDNs in disease progression and thrombosis formation, along with potential therapeutic strategies targeting neutrophil and NETs formation.

It is necessary to promote harmony between the economic growth of tourism and the resource environment to achieve the green and sustainable development of China’s tourism industry. The research objects were taken in 30 provinces and cities in China. The green innovation efficiency of tourism is measured and evaluated based on the super-efficient SBM model and Moran index. The spatial and temporal heterogeneity of the influencing factors of green innovation efficiency is analyzed using the GWR model. The study shows that: (1) The level of green innovation efficiency of the tourism industry as a whole keeps improving during the study period, but the development is uneven among eastern, central, and western provinces. (2) The spatial correlation of the green innovation efficiency of the tourism industry in 30 provinces and cities keeps getting closer and closer, and some regions show the characteristics of spatial aggregation. (3) The green innovation efficiency of the tourism industry is affected by various factors, such as the level of economic development and the level of professional development of the tourism industry. (4) Tourism green innovation efficiency is influenced by various factors, such as economic development level and tourism professional development level, and there are apparent intensity differences and spatial heterogeneity among various influencing factors. Finally, reasonable countermeasures are proposed to promote the overall improvement and balanced development of green innovation efficiency in China’s tourism industry.