No abstract

Ni complex was prepared from bipyridine dicarboxylic acid and Ni salt. Then, the Ni complex was reacted with Al salt in dimethyl formamide in an autoclave to prepare metal-organic framework (MOF) compounds containing Ni-complex. IR analysis indicated disappearance of absorption peaks related to carboxylic acid, and nitrogen-adsorption isotherm analysis revealed the presence of micropores. MOF compounds containing Ni complex were used as catalysts for oligomerization of ethylene. Diethyl aluminum chloride or MOF containing Ni complex was inactive for the reaction. However, MOF compounds containing Ni complex used with diethyl aluminum chloride had high potential as a catalyst for the oligomerization of ethylene with high selectivity for linear butenes.

One-handed helical oligo(p-benzamide)s were induced via the domino effect based on the planar-axial-helical chirality relay triggered by a planar chiral transition-metal complex at the terminal position as the single chiral source.

CUB domain‐containing protein‐1 (CDCP1) is a trans‐membrane protein predominantly expressed in various cancer cells and involved in tumor progression. CDCP1 is phosphorylated at tyrosine residues in the intracellular domain by Src family kinases and recruits PKCδ to the plasma membrane through tyrosine phosphorylation‐dependent association with the C2 domain of PKCδ, which in turn induces a survival signal in an anchorage‐independent condition. In this study, we used our cell‐free screening system to identify a small compound, glycoconjugated palladium complex (Pd‐Oqn), which significantly inhibited the interaction between the C2 domain of PKCδ and phosphorylated CDCP1. Immunoprecipitation assays demonstrated that Pd‐Oqn hindered the intercellular interaction of phosphorylated CDCP1 with PKCδ and also suppressed the phosphorylation of PKCδ but not that of ERK or AKT. In addition, Pd‐Oqn inhibited the colony formation of gastric adenocarcinoma 44As3 cells in soft agar as well as their invasion. In mouse models, Pd‐Oqn markedly reduced the peritoneal dissemination of gastric adenocarcinoma cells and the tumor growth of pancreatic cancer orthotopic xenografts. These results suggest that the novel compound Pd‐Oqn reduces tumor metastasis and growth by inhibiting the association between CDCP1 and PKCδ, thus potentially representing a promising candidate among therapeutic reagents targeting protein–protein interaction.

Laser-ablated polyyne molecules, H(C≡C)nH, were separated by size in solutions and co-condensed with excess hexane molecules at a cryogenic temperature of 20 K in a vacuum system. The solid matrix samples containing C8H2, C10H2, and C12H2 molecules were irradiated with UV laser pulses and the phosphorescence 0–0 band was observed at 532, 605, and 659 nm, respectively. Vibrational progression was observed for the symmetric stretching mode of the carbon chain in the ground state with increments of ~2190 cm−1 for C8H2, ~2120 cm−1 for C10H2, and ~2090 cm−1 for C12H2. Temporal decay analysis of the phosphorescence intensity revealed the lifetimes of the triplet state as ~30 ms for C8H2, ~8 ms for C10H2, and ~4 ms for C12H2. The phosphorescence excitation spectrum reproduces UV absorption spectra in the hexane solution and in the gas phase at ambient temperature, although the excitation energy was redshifted. The symmetry-forbidden vibronic transitions were observed for C10H2 by lower excitation energies of 25,500–31,000 cm−1 (320–390 nm). Detailed phosphorescence excitation patterns are discussed along the interaction of the polyyne molecule and solvent molecules of hexane.